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Evidence Behind Our Claims

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“What if the choice of bone cement could make the difference in long-term success?1

Independent national registries consistently demonstrate that implant survival is influenced by the type of bone cement used. Across multiple countries, PALACOS® bone cements show lower revision rates than other brands over follow-up periods of up to 20 years. This highlights that bone cement is not just a technical detail — it can be a decisive factor for the long-term success of an implant.

…and deliver outcomes supported by decades of clinical evidence.”2

PALACOS® bone cements have been available since 1959, making them one of the most established and well-documented cement brands in modern arthroplasty.

Over the decades, PALACOS® has become the most extensively studied bone cement worldwide, with more than 360 PubMed-listed publications reflecting its widespread use and scientific relevance.

  • Pilz R, Hanstein T. Clinical evidence of the antibiotic-loaded bone cement PALACOS® R+G. Der Orthopäde. 2018; 47(12):1002–1010. Go to the study on ResearchGate
  • Heraeus Medical: Market availability of PALACOS® since 1959.

“With over 65 years of experience and more than 40 million procedures worldwide.”3

Few medical devices can claim such a track record. The global usage of PALACOS® demonstrates the trust surgeons have placed in its reliability and performance for more than six decades.

  • Heraeus Medical data on file: Estimated based on average cement use per arthroplasty procedure.

“PALACOS® is the Gold Standard in bone cement.”4

PALACOS® R+G is widely regarded as the reference standard among antibiotic-loaded bone cements. Multiple independent studies have used it as the benchmark for comparing mechanical properties, handling performance, and antibiotic elution profiles.

  • Olerud F, Olsson C, Flivik G. Comparison of Refobacin® Bone Cement and PALACOS® R+G in total hip arthroplasty: an RSA study with two years’ follow-up. Hip International. 2014; 24(1): 56-62. Go to the study on PubMed
  • Jørgensen PB, Lamm M, Søballe K, Stilling M. Equivalent hip stem fixation by Hi-Fatigue® G and PALACOS® R+G bone cement: a randomized radiostereometric controlled trial of 52 patients with 2 years’ follow-up. Acta Orthopaedica. 2019; 90(3): 237-242. Go to the study on PubMed
  • Coraça-Huber DC, Humez M, Kühn KD. Antibiotic elution and antibacterial activity of gentamicin-loaded PMMA bone cements: A comparative analysis. Journal of Bone and Joint Infection. 2025, 13, 2174. (in press / online ahead of print). Go to the study on PubMed
  • Dietz M, Fölsch C, Jahnke M, et al. Elution efficacy and antibacterial activity of modern ALBCs: comparison of PALACOS® MV+G and competitors. Journal of Arthroplasty. 2024;39(5):1020–1030. Go to the study on PubMed
  • Meeker DG, et al. Comparison of antibiotic elution and mechanical properties of commercial PMMA bone cements. Journal of Arthroplasty. 2022;37(8):1528–1537. Go to the study on PubMed
  • Pilz R, Hanstein T. A Literature Review of the Clinical Evidence Situation of Bone Cements. Der Orthopäde. 2018;47(12):1002–1010. Go to the study on ResearchGate

“PALACOS® demonstrates consistently lower revision rates than other bone cements — in both plain and ALBC.”1

Recent registry analyses and real-world evidence underline that PALACOS® outperforms competitors across different formulations. This translates into fewer revisions, lower complication risks, and ultimately better patient outcomes.

PALACOS Always a Step Ahead

Evidence List

Registry Data

Publications