Evidence Behind Our Claims

“PALACOS^® demonstrates consistently lower revision rates than other bone cements — in both plain and ALBC.”¹

Recent registry analyses and real-world evidence underline that PALACOS^® outperforms competitors across different formulations. This translates into fewer revisions, lower complication risks, and ultimately better patient outcomes.

National Joint Registry (NJR) UK, Annual Reports 2005 - 2024. Go to the Website of NJR
Catalan Arthroplasty Register (RaCat). Revision and Outcomes Report 2025. Go to the Website of Generalitat de Catalunya
Perez-Prieto D, et al. 2025 (Catalonia Registry data): Analysis of >22,000 TKA cases showed lower revision risk with PALACOS^® antibiotic-loaded cement compared to other ALBC. Go to the study on PubMed

“What if the choice of bone cement could make the difference in long-term success?¹

Independent national registries consistently demonstrate that implant survival is influenced by the type of bone cement used. Across multiple countries, PALACOS^® bone cements show lower revision rates than other brands over follow-up periods of up to 20 years. This highlights that bone cement is not just a technical detail — it can be a decisive factor for the long-term success of an implant.

National Joint Registry (NJR) for UK, Annual Reports from 2005 - 2025. Go to the Website of NJR
Swedish Arthroplasty Register (SAR). Go to the Website of SAR
Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR). Go to the Website of AOANJRR
Catalan Arthroplasty Register (RaCat). Go to the Website of Generalitat de Catalunya

…and deliver outcomes supported by decades of clinical evidence.”²

PALACOS^® bone cements have been available since 1959, making them one of the most established and well-documented cement brands in modern arthroplasty.

Over the decades, PALACOS^® has become the most extensively studied bone cement worldwide, with more than 360 PubMed-listed publications reflecting its widespread use and scientific relevance.

Pilz R, Hanstein T. Clinical evidence of the antibiotic-loaded bone cement PALACOS^® R+G. Der Orthopäde. 2018; 47(12):1002–1010. Go to the study on ResearchGate
Heraeus Medical: Market availability of PALACOS^® since 1959.

“With over 65 years of experience and more than 40 million procedures worldwide.”³

Few medical devices can claim such a track record. The global usage of PALACOS^® demonstrates the trust surgeons have placed in its reliability and performance for more than six decades.

Heraeus Medical data on file: Estimated based on average cement use per arthroplasty procedure.

“PALACOS^® is the Gold Standard in bone cement.”⁴

PALACOS^® R+G is widely regarded as the reference standard among antibiotic-loaded bone cements. Multiple independent studies have used it as the benchmark for comparing mechanical properties, handling performance, and antibiotic elution profiles.

Olerud F, Olsson C, Flivik G. Comparison of Refobacin^® Bone Cement and PALACOS^® R+G in total hip arthroplasty: an RSA study with two years’ follow-up. Hip International. 2014; 24(1): 56-62. Go to the study on PubMed
Jørgensen PB, Lamm M, Søballe K, Stilling M. Equivalent hip stem fixation by Hi-Fatigue^® G and PALACOS^® R+G bone cement: a randomized radiostereometric controlled trial of 52 patients with 2 years’ follow-up. Acta Orthopaedica. 2019; 90(3): 237-242. Go to the study on PubMed
Coraça-Huber DC, Humez M, Kühn KD. Antibiotic elution and antibacterial activity of gentamicin-loaded PMMA bone cements: A comparative analysis. Journal of Bone and Joint Infection. 2025, 13, 2174. (in press / online ahead of print). Go to the study on PubMed
Dietz M, Fölsch C, Jahnke M, et al. Elution efficacy and antibacterial activity of modern ALBCs: comparison of PALACOS^® MV+G and competitors. Journal of Arthroplasty. 2024;39(5):1020–1030. Go to the study on PubMed
Meeker DG, et al. Comparison of antibiotic elution and mechanical properties of commercial PMMA bone cements. Journal of Arthroplasty. 2022;37(8):1528–1537. Go to the study on PubMed
Pilz R, Hanstein T. A Literature Review of the Clinical Evidence Situation of Bone Cements. Der Orthopäde. 2018;47(12):1002–1010. Go to the study on ResearchGate

Evidence List

Registry Data

Publications

Evidence Behind Our Claims

“PALACOS® demonstrates consistently lower revision rates than other bone cements — in both plain and ALBC.”1

AAHKS 2025: PALACOS® Video

“What if the choice of bone cement could make the difference in long-term success?1

…and deliver outcomes supported by decades of clinical evidence.”2

“With over 65 years of experience and more than 40 million procedures worldwide.”3