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Clinical Evidence

The use of high-dose dual-impregnated antibiotic-laden cement with hemiarthroplasty for the treatment of a fracture of the hip: 
The fractured hip infection trial

Sprowson AP, Jensen C, Chambers S, Parson NR, Aradhyula NM, Carluke I, Inman D, Reed MR
Bone Joint J. 2016; 98-B: 1534-1541.

At a Glance

  • Significant reduction in the rates of deep as well as of deep and superficial surgical site infections (SSI) within 12 months following prosthesis fixation with COPAL® G+C vs. low-dose single antibiotic-loaded bone cement (SALBC)

    • Deep SSI rate of 1.1% in the COPAL® G+C group vs. 3.5% in the SALBC group

    • Deep and superficial SSI rate of 1.7% in COPAL® G+C group vs. 5.3% in the SALBC group
  • Complications did not differ between the two groups 

Study Details

  • Prospective, double-blinded, quasi-randomised controlled study in patients with cemented hemiarthroplasty after fractured neck of femur (FNOF)
  • Comparison of prosthesis fixation with high-dose dual antibiotic-loaded bone cement (DALBC) COPAL® G+C vs. SALBC
  • Primary endpoint: deep SSI within 12 months following surgery  
Study design: Patients with FNOF (n = 848) with cemented hemiartroplasty devided into 2 groups: SALBC (n = 448) and COPAL G+C (n = 400)
Study Design: quasi-randomised trial in 848 patients with cemented hemiarthroplasty after FNOF. Control group: 448 patients randomised to SALBC; intervention group: 400 patients randomised to COPAL G+C. Primary endpoint was deep SSI at one year after surgery. Figure based on Sprowson et al. (2016)

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The use of high-dose dual-impregnated antibiotic-laden cement with hemiarthroplasty for the treatment of a fracture of the hip: The fractured hip infection trial

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