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Clinical Evidence

Antibiotic resistance profiles of deep surgical site infections in hip hemiarthroplasty; comparing low dose single antibiotic versus high dose dual antibiotic impregnated cement

Tyas B, Marsh M, Oswald T, Refaie R, Molyneux C, Reed M
J Bone Joint Infect 2018; 3: 123-129.

At a glance

  • Significantly lower infection rate with COPAL® G+C compared to low-dose single antibiotic-loaded bone cement (SALBC) in patients who had received cemented hip hemiarthroplasty between April 2008 and December 2014 (1.2% vs. 3.4%)
  • COPAL® G+C does not drive antibiotic resistance in these patients

  • Retrospective study in patients with cemented hemiarthroplasty between April 2008 and December 2014:

    • Including a quasi-randomised trial running from April 2008 to May 2012 

    • Following completion of the trial, switch from SALBC to high-dose dual antibiotic-loaded bone cement (DALBC) as standard of care for hip hemiarthroplasty in all (non-trial) patients

  • Comparison of implant fixation with COPAL® G+C vs. SALBC
  • Endpoints: infection rate, causative organisms, resistance profiles
Study Design: Retrospective study in 1,941 patients with cemented hemiarthroplasty between April 2008 and December 2014 (SALBC: 681 patients, COPAL G+C: 1,260 patients). Study period includes a quasi-radomised trial running from April 2008 to May 2012 with 464 patients randomised to SALBC and 384 patients randomised to COPAL G+C. Additionally, 217 non-trial patients receiving SALBC between April 2008 and May 2012 as well as 876 patients receiving COPAL G+C between May 2012 and December 2014 are included. Figure based on Tyas et al. (2018)

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Antibiotic resistance profiles of deep surgical site infections in hip hemiarthroplasty; comparing low dose single antibiotic versus high dose dual antibiotic impregnated cement

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