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Clinical Evidence Fractured Neck of Femur

Clinical evidence for the use of COPAL® G+C, a high-dose dual antibiotic-loaded bone cement, for prosthesis fixation after fractured neck of femur.

Fractured neck of femur

Prosthetic Arthroplasty in Fractured Neck of Femur

Proximal fractures of the neck of femur (FNOF) are typical injuries within the elderly.1,2,3 Immediate restoration of weight-bearing capacity and prevention of complications – particularly of surgical site infection (SSI) – are very important. Cemented hemiarthroplasty represents a good surgical treatment option, particularly for patients with reduced mobility, cognition and/or reduced life expectancy.4
Application of a dual antibiotic-loaded bone cement (DALBC) such as COPAL® G+C can lower the risk of periprosthetic joint infection and its sequelae in vulnerable patients effectively.4

Sprowson et al. Bone Joint J 2016

The use of high-dose dual-impregnated antibiotic-laden cement with hemiarthroplasty for the treatment of a fracture of the hip: The fractured hip infection trial

 

Prospective, double-blinded, quasi-randomised trial in 848 patients with cemented hemiarthroplasty due to FNOF: infection rates following the use of COPAL® G+C vs. single antibiotic-loaded bone cement (SALBC).

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Tyas et al. J Bone Joint Infect 2018

Antibiotic resistance profiles of deep surgical site infections in hip hemiarthroplasty; comparing low dose single antibiotic versus high dose dual antibiotic impregnated cement

 

Retrospective analysis in 1,941 patients with cemented hemiarthroplasty due to hip fracture: infection rates and antibiotic resistance following the use of COPAL® G+C vs. SALBC.

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Savage et al. Ann R Coll Surg Engl 2019

Arthroplasty infection rates in fractured neck of femur: single vs dual antibiotic cement

 

Retrospective and prospective non-randomised analysis in 206 patients with cemented (hemi-)arthroplasty due to FNOF: infection rates following the use of COPAL® G+C vs. SALBC.

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Agni et al. Lancet 2023

High-dose dual-antibiotic loaded cement for hip hemiarthroplasty in the UK (WHiTE 8): a randomised controlled trial

 

Prospective, multicentre, randomised, controlled trial (WHiTE 8) in 4,936 patients following cemented hemiarthroplasty due to FNOF: infection rates following the use of COPAL® G+C vs. SALBC.

Click to see study details